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Triethylamine → 1-(2-Fluoro-4-nitrophenyl)piperidin-4-ol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Piperidin-4-ol | HCID 79341 | — |
| 反応物 | 1,2-Difluoro-4-nitrobenzene | HCID 123053 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | 1-(2-Fluoro-4-nitrophenyl)piperidin-4-ol | HCID 26598221 | 80.5% |
反応手順
To a solution of piperidin-4-ol (11.11 g, 0.11 mol) and Et3N (12.14 g, 0.12 mol) in EtOAc (500 mL) was added 1,2-difluoro-4-nitrobenzene (15.91 g, 0.10 mol). The mixture was stirred at rt for 24 h, and washed with water (200 mL×4). The organic phase was dried over anhydrous Na2SO4 and concentrated in vacuo to give the title compound as orange oil (19.35 g, 80%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09434695B2 |
| 出典データセット | uspto-grants-2016_09 |
| ORD ID | ord-a558440d17004c44b2cb7ddab9285113 |
| 出典メモ | uspto-grants-2016_09 |