関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Indole | HCID 798 | — |
| 反応物 | Benzoyl chloride | HCID 7412 | — |
| 反応物 | Quinoline 1-oxide | HCID 15366 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 2-(1H-Indol-3-yl)quinoline | HCID 12406622 | 6% |
反応手順
To a solution of quinoline-N-oxide (0.5 mmol) in 2 mL DCM at 0° C. in a 3 mL plastic tube fitted with a frit was added 58 uL of benzoyl chloride (0.5 mmol). The reaction mixture was stirred for 15 min at 0° C. and then indole (0.5 mmol) was added. The reaction was warmed to 20 ° C. and stirred for 4 h. The solid precipitate was filtered and washed with DCM (3×2 mL) to give solid 2-(3-indolyl)quinoline (6-100% yield).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06172084B2 |
|---|
| 出典データセット | uspto-grants-2001_01 |
|---|
| ORD ID | ord-f1edd849e7ba4f11bb333748e3a1c4e2 |
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| 出典メモ | uspto-grants-2001_01 |
|---|
