化工社化工社 化学情報印刷レポート · 研究参考用
Methanol → (2s)-(-)-1-(4-Indolyloxy)-3-(7,8-dimethoxy-2,3,4,5-tetrahydro-1h-3-benzazepin-3-yl)-2-propanol ethanedioate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | Oxalic Acid | HCID 971 | — |
| 反応物 | (2s)-Glycidyl indol-4-yl ether | HCID 10943254 | — |
| 反応物 | 7,8-Dimethoxy-2,3,4,5-tetrahydro-1H-3-benzazepine | HCID 12923429 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | (2s)-(-)-1-(4-Indolyloxy)-3-(7,8-dimethoxy-2,3,4,5-tetrahydro-1h-3-benzazepin-3-yl)-2-propanol ethanedioate | HCID 131719697 | — |
反応手順
The title compound was prepared in similar fashion from (S)-(+)-4-(oxiranylmethoxy)-1H-indole and 7,8-dimethoxy-2,3,4,5-tetrahydro-1H-3-benzazepine. The resulting free base was dissolved in ethyl acetate, and precipitated with one equivalent of oxalic acid in ethyl acetate in 48% overall yield. FDMS m/e=396 (M+ of free base). α[D]589=−9.34 (c=0.47, methanol).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06172073B2 |
| 出典データセット | uspto-grants-2001_01 |
| ORD ID | ord-206b6bb6bd77434e920a1c74865a1c3c |
| 出典メモ | uspto-grants-2001_01 |