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(5-Chloro-2-methoxypyridin-4-yl)boronic acid → 5-Chloro-4-[5-chloro-2-(trifluoromethyl)phenyl]-2-methoxypyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (5-Chloro-2-methoxypyridin-4-yl)boronic acid | HCID 11030558 | — |
| 反応物 | 2-Bromo-4-chloro-1-(trifluoromethyl)benzene | HCID 20269857 | — |
| 触媒 | XPhos Palladacycle | HCID 54751079 | — |
| 生成物 | 5-Chloro-4-[5-chloro-2-(trifluoromethyl)phenyl]-2-methoxypyridine | HCID 117605620 | — |
反応手順
443 mg (2.20 mmol) of 5-chloro-2-methoxypyridin-4-ylboronic acid and 571 mg (2.20 mmol) of 2-bromo-4-chloro-1-(trifluoromethyl)benzene in the presence of XPhos precatalyst were reacted according to General Method 2B. Yield: 193 mg (purity 93%, 25% of theory)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09434690B2 |
| 出典データセット | uspto-grants-2016_09 |
| ORD ID | ord-fa6e63b98ed947ad9d7b691e79ba8e50 |
| 出典メモ | uspto-grants-2016_09 |