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Temozolomide → HCID 3352880、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Temozolomide | HCID 5394 | — |
| 反応物 | 2,4-Bis(4-phenoxyphenyl)-2,4-dithioxo-1,3,2,4-dithiadiphosphetane | HCID 11813414 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | HCID 3352880 | HCID 3352880 | — |
反応手順
A mixture of temozolomide (3 g, 15.5 mmol) and Belleau's reagent (4.49 g, 8.5 mmol) was refluxed in DCM (80 mL) overnight. The reaction was quenched with water and the precipitate was filtered and washed with diethyl ether to give the pure title compound as an orange solid. (2.75 g, 84%). δH, (DMSO-d6): 9.92 (1H, s), 9.45 (1H, s), 8.81 (1H, s), 3.85 (3H, s).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09024018B2 |
| 出典データセット | uspto-grants-2015_05 |
| ORD ID | ord-25cdbd6d9c284c5b9de55719f0c358de |
| 出典メモ | uspto-grants-2015_05 |