化工社化工社 化学情報印刷レポート · 研究参考用
1H-Benzimidazole-2-carboxaldehyde → (1H-benzimidazol-2-ylmethylene)(1-methylpiperidin-4-yl)amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1H-Benzimidazole-2-carboxaldehyde | HCID 76826 | — |
| 反応物 | 4-Amino-1-methylpiperidine | HCID 2737531 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | (1H-benzimidazol-2-ylmethylene)(1-methylpiperidin-4-yl)amine | HCID 136335844 | — |
反応手順
1H-Benzimidazole-2-carboxaldehyde (781 mg, can be prepared according to Fegy, K. Angewandte Chemie Int Ed, 1998, vol. 37, 1270-1273), 4-amino-1-methylpiperidine (781 mg) and 4 Å molecular sieves (15 g) in ethanol (100 mL) are heated under reflux for 4 h. The mixture is then filtered and the filtrate concentrated under reduced pressure to yield (1H-benzimidazol-2-ylmethylene)(1-methylpiperidin-4-yl)amine as a beige solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09029357B2 |
| 出典データセット | uspto-grants-2015_05 |
| ORD ID | ord-09ad8afe261641bbbf1993569c1c8080 |
| 出典メモ | uspto-grants-2015_05 |