関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Ammonium Carbonate | HCID 517111 | — |
| 反応物 | N,alpha-bis-formyl-N-(1,2,3,4-tetrahydronaphthalen-1-yl)glycine methyl ester | HCID 19794118 | — |
| 溶媒 | O-Xylene | HCID 7237 | — |
| 生成物 | 3-(1,2,3,4-Tetrahydronaphthalen-1-YL)-3H-imidazole-4-carboxylic acid methyl ester | HCID 14497624 | — |
反応手順
33.0 g of ammonium carbonate are added at room temperature to a solution of 15.5 g of N,α-bis-formyl-N-(1,2,3,4-tetrahydronaphthalen-1-yl)glycine methyl ester in 300 ml of xylene. The mixture is heated to 70° C. for 1 hour then the temperature is raised to 120° C. for 3 hours. After concentration the 1-(1,2,3,4-tetrahydronaphthalen-1-yl)-5-imidazolecarboxylic acid methyl ester precipitates from the solution, having a melting point of 63° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05246915 |
|---|
| 出典データセット | uspto-grants-1993_09 |
|---|
| ORD ID | ord-7700c29acc3b4bd1902fd09ff1183544 |
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| 出典メモ | uspto-grants-1993_09 |
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