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HRID 57889作成日：2026年10月24日
N,N'-Dimethylethylenediamine → Tert-butyl 4-[6-(6-chloropyrazolo[4,3-c]pyridin-1-yl)pyrazin-2-yl]-1,4-diazepane-1-carboxylate
https://huagongshe.com/ja/reaction/57889
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | N,N'-Dimethylethylenediamine | HCID 8070 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 6-Chloro-1H-pyrazolo(4,3-c)pyridine | HCID 56932109 | — |
| 反応物 | Tert-butyl 4-(6-bromopyrazin-2-yl)-1,4-diazepane-1-carboxylate | HCID 86707065 | — |
| 触媒 | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | Tert-butyl 4-[6-(6-chloropyrazolo[4,3-c]pyridin-1-yl)pyrazin-2-yl]-1,4-diazepane-1-carboxylate | HCID 86707066 | 74% |
反応手順
To a mixture of tert-butyl 4-(6-bromopyrazin-2-yl)-1,4-diazepane-1-carboxylate (0.45 g, 1.26 mmol) and 6-chloro-1H-pyrazolo[4,3-c]pyridine (192 mg, 1.26 mmol) in dioxane (10 mL) was added CuI (19 mg, 0.1 mmol), N1,N2-dimethylethane-1,2-diamine (6.3 mmol, 0.55 g), K2CO3(3.78 mmol, 0.53 g). The reaction mixture was heated at 100° C., which was monitored by LCMS. After completion of the reaction, it was concentrated under reduced pressure. The crude material was purified by silica gel chromatography using petroleum ether/ethyl acetate (5% to 50%) as eluting solvents to afford tert-butyl 4-(6-(6-chloro-1H-pyrazolo[4,3-c]pyridin-1-yl)pyrazin-2-yl)-1,4-diazepane-1-carboxylate as yellow solid (0.4 g, 74%). MS (ESI) m/z: δ 430 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US09434725B2 |
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| 出典データセット | uspto-grants-2016_09 |
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| ORD ID | ord-eccdae8215514db682f3351f33148b02 |
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| 出典メモ | uspto-grants-2016_09 |
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