関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 2,3-Dibromothiophene | HCID 76590 | — |
| 反応物 | Tetrabutylammonium Fluoride | HCID 2724141 | — |
| 反応物 | 2-Fluoro-3-(tributylstannyl)pyridine | HCID 11090319 | — |
| 触媒 | HCID 178418476 | HCID 178418476 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 溶媒 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 生成物 | 3-Bromo-2-(2-fluoropyridin-3-yl)thiophene | HCID 15408568 | 40.7% |
反応手順
A mixture of 2,3-dibromothiophene (2.86 g), 2-fluoro-3-tributylstannylpyridine (3.93 g), Pd(Ph3P)2Cl2 (0.153 g) in N-methylpyrrolidinone (25 mL) was heated at 75° C. under argon for 3.5 hours. Tetrabutylammonium fluoride (1M in tetrahydrofuran, 10 mL) was added and the mixture was stirred for 3 hours. The mixture was diluted with ethyl acetate, washed with water, dried, filtered and evaporated. Chromatography of the residue over silica gel gave 3-bromo-2-(2-fluoropyridin-3-yl)thiophene (1.07 g) as an oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05919779 |
|---|
| 出典データセット | uspto-grants-1999_07 |
|---|
| ORD ID | ord-74d82bbcf3e24e00a96e5df58432d02b |
|---|
| 出典メモ | uspto-grants-1999_07 |
|---|
