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Triethylamine → Raloxifene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Raloxifene Hydrochloride | HCID 54900 | — |
| 反応物 | Linolenoyl chloride | HCID 5702742 | — |
| 触媒 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | Raloxifene | HCID 5035 | — |
反応手順
This derivative was prepared in a manner similar to Example 1, using 2.6 g (0.005 mol) of Raloxifene HCl, 2 g (0.02 mol) of triethylamine, 20 mg of DMAP, and 3.2 g (0.01 mol) of linolenoyl chloride in 250 mL of THF. The final product was chromatographed on a silica gel column eluted with EtOAc-hexane (8:2). This yielded 3.21 g of the title compound as clear oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05929092 |
| 出典データセット | uspto-grants-1999_07 |
| ORD ID | ord-b83cb7783d2f4c4b9d00bd785d518b9b |
| 出典メモ | uspto-grants-1999_07 |