関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 4-Fluoro-N-methylaniline | HCID 68024 | — |
| 反応物 | 2-Bromo-isonicotinic acid methyl ester | HCID 3847768 | — |
| 試薬 | Cesium carbonate | HCID 10796 | — |
| 触媒 | 2-(Dicyclohexylphosphino)biphenyl | HCID 2734216 | — |
| 触媒 | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | methyl 2-(4-fluoro-N-methylanilino)pyridine-4-carboxylate | HCID 108379206 | 0% |
反応手順
In a 100 mL round-bottomed flask (t=g) was biphenyl-2-yldicyclohexylphosphine (0.024 g, 0.07 mmol), methyl 2-bromoisonicotinate (.1 g, 0.46 mmol), and 4-fluoro-N-methylaniline (0.070 g, 0.56 mmol) in toluene (3 mL) to give a purple suspension. Pd2dba3 (0.021 g, 0.02 mmol) and CS2CO3 (0.211 g, 0.65 mmol) were added. Flask was placed in an oil bath at 85 °C. LC/MS taken at 1, 2 and 4 hours indicated reaction was not progressing. Reaction was discarded.
情報源と証拠
| 出典データセット | 750 AstraZeneca ELN dataset |
|---|
| ORD ID | ord-8fdcadcf8d694b72a4ad9ff8119e3e79 |
|---|
| 出典メモ | 750 AstraZeneca ELN dataset |
|---|
