関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 3-Bromocyclohexene | HCID 137057 | — |
| 反応物 | Methyl 4-acetamido-5-chloro-2-hydroxybenzoate | HCID 13329485 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Methyl 2-(cyclohexen-3-yloxy)-4-acetylamino-5-chlorobenzoate | HCID 14621154 | — |
反応手順
A mixture of 2.5 g methyl 4-acetylamino-5chlorosalicylate, 2 g of 3-bromocyclohexene, 2 g K2CO3 and 30 ml DMF are combined and heated at 110° C. overnight. The reaction mixture is then poured into water, filtered, dried and then extracted into ether. The ether solution is treated with charcoal, filtered and evaporated to dryness to obtain methyl 2-(cyclohexen -3-yloxy)-4-acetylamino-5-chlorobenzoate. This is then purified by recrystallization from ether/hexane. (M.P. 100°-102° C.)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05246942 |
|---|
| 出典データセット | uspto-grants-1993_09 |
|---|
| ORD ID | ord-a899c80f18084f9c9768df737127ddcc |
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| 出典メモ | uspto-grants-1993_09 |
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