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HRID 5900作成日：2026年10月23日

4-Methoxy-3-methylbenzyl chloride → (RS)-2-(Diphenylacetyl)-1,2,3,4-tetrahydro-6-methoxy-5-[(4-methoxy-3-methylphenyl)methoxy]-3-isoquinolinecarboxylic acid, ethyl ester

https://huagongshe.com/ja/reaction/5900

反応式

関与物質

役割名称HCID仕込み量
反応物4-Methoxy-3-methylbenzyl chlorideHCID 143742—
反応物(RS)-2-(Diphenylacetyl)-1,2,3,4-tetrahydro-5-hydroxy-6-methoxy-3-isoquinolinecarboxylic acid, ethyl esterHCID 15296729—
生成物(RS)-2-(Diphenylacetyl)-1,2,3,4-tetrahydro-6-methoxy-5-[(4-methoxy-3-methylphenyl)methoxy]-3-isoquinolinecarboxylic acid, ethyl esterHCID 15230314—

反応手順

This compound is prepared from the phenol derivative of Example 31 and 4-methoxy-3-methyl benzyl chloride by a procedure similar to that in Example 32. The product is purified by silica gel chromatography; tlc (1:1 ethyl-acetate/hexane), one spot, Rf 0.7.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US05246943
出典データセットuspto-grants-1993_09
ORD IDord-5863e731e9c84c6190da1db07ffc1880
出典メモuspto-grants-1993_09