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Hydrochloric Acid → (4-Chloro-3-nitrobenzyl)amine hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | N-(4-chloro-3-nitrobenzyl)-2,2,2-trifluoroacetamide | HCID 19879857 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | (4-Chloro-3-nitrobenzyl)amine hydrochloride | HCID 18796739 | 221.7% |
反応手順
To a solution of N-(4-chloro-3-nitrobenzyl)-2,2,2-trifluoroacetamide (0.800 g) in methanol (20 mL) was added conc. HCl (2.0 ml). The reaction mass was refluxed for 18 h. Excess solvent was removed under vacuum to afford 0.700 g of desired product. 1H NMR (300 MHz, DMSO d6): δ 7.18 (s, 1H), 7.35 (s, 1H), 7.52 (s, 1H), 7.86 (s, 2H); 8.28 (s, 1H), 8.72 (br s, 2H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09439890B2 |
| 出典データセット | uspto-grants-2016_09 |
| ORD ID | ord-f46bdd934be84074a9cf3af957768643 |
| 出典メモ | uspto-grants-2016_09 |