化工社化工社 化学情報印刷レポート · 研究参考用
Ammonia → 2-Fluoro-4-iodobenzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ammonia | HCID 222 | — |
| 反応物 | Dichloromethane | HCID 6344 | — |
| 反応物 | Oxalyl chloride | HCID 65578 | — |
| 反応物 | 2-Fluoro-4-iodobenzoic acid | HCID 2774516 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 2-Fluoro-4-iodobenzamide | HCID 21904755 | — |
反応手順
The title compound was prepared according to the procedure described in step-2 of Intermediate-26 by using 2-fluoro-4-iodobenzoic acid (5.00 g, 18.0 mmol), oxalyl chloride (2.0 mL, 22.0 mmol), ammonia gas, DCM (100 mL) and THF (100 mL) to afford 2.00 g of the desired product. 1H NMR (300 MHz, DMSO d6): δ 7.40 (t, J=7.8 Hz, 1H), 7.63-7.76 (m, 1H); MS (m/z): 266.19 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09439890B2 |
| 出典データセット | uspto-grants-2016_09 |
| ORD ID | ord-608a80d74a534b1ca94e9867f20cd1e0 |
| 出典メモ | uspto-grants-2016_09 |