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Dimethyl Sulfoxide → 2-(4-Chlorophenyl)-5-phenylvaleronitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethyl Sulfoxide | HCID 679 | — |
| 反応物 | (3-Bromopropyl)benzene | HCID 12503 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 4-Chlorobenzyl cyanide | HCID 241582 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 2-(4-Chlorophenyl)-5-phenylvaleronitrile | HCID 14147722 | — |
反応手順
2 ml of an aqueous sodium hydroxide (1.08 g) solution was added to a 10 ml solution of dimethylsulfoxide containing 1.0 g (6.6 mmole) of 4-chlorophenylacetonitrile and 1.3 g (6.6 mmole) of 1-bromo-3-phenylpropane at room temperature. After stirring for 2 hours under the same conditions, water was added to the reaction mixture and the mixture was extracted with 10 ml of n-hexane, dried, and condensed under reduced pressure to obtain 1.78 g (yield: quantitative) of 2-(4-chlorophenyl)-5-phenylvaleronitrile.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05246958 |
| 出典データセット | uspto-grants-1993_09 |
| ORD ID | ord-fc328861075c4601a239c2cf487b943a |
| 出典メモ | uspto-grants-1993_09 |