化工社化工社 化学情報印刷レポート · 研究参考用
Sulfuric Acid → isopropyl 5-fluoro-3-methyl-1H-indole-2-propanoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sulfuric Acid | HCID 1118 | — |
| 反応物 | 4-Fluorophenylhydrazine hydrochloride | HCID 69981 | — |
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 反応物 | Ethyl 4-oxohexanoate | HCID 12271528 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 生成物 | isopropyl 5-fluoro-3-methyl-1H-indole-2-propanoate | HCID 19794669 | — |
反応手順
A mixture of 1-(4-fluorophenyl)hydrazine hydrochloride (1.03 g), ethyl 4-oxo-hexanoate (1.0 g), 2-propanol (25 ml) and H2SO4 is refluxed under nitrogen for 9 hours. After cooling the mixture is poured into a aqueous solution of NaHCO3, extracted with AcOEt and evaporated to dryness to yield 1.45 g of isopropyl 5-fluoro-3-methyl-1H-indole-2-propanoate.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05246957 |
| 出典データセット | uspto-grants-1993_09 |
| ORD ID | ord-7032a768e4ff40098e40773662a0af2f |
| 出典メモ | uspto-grants-1993_09 |