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4-Chlorobenzyl cyanide → 3-(4-Chloro-phenyl)-5-[2-(2-fluoro-phenyl)-2H-pyrazol-3-yl]-benzo[c]isoxazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Chlorobenzyl cyanide | HCID 241582 | — |
| 反応物 | 1-(2-fluoro-phenyl)-5-(4-nitro-phenyl)-1H-pyrazole | HCID 90032765 | — |
| 生成物 | 3-(4-Chloro-phenyl)-5-[2-(2-fluoro-phenyl)-2H-pyrazol-3-yl]-benzo[c]isoxazole | HCID 72725267 | — |
反応手順
The title compound, light yellow solid (96 mg, 70%), MS (ISP) m/z=390.2 [(M+H)+], mp 191° C., was prepared in accordance with the general method of example 1 from 1-(2-fluoro-phenyl)-5-(4-nitro-phenyl)-1H-pyrazole (intermediate B) (100 mg, 353 μmol) and commercially available 2-(4-chloro-phenyl)-acetonitrile.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09440962B2 |
| 出典データセット | uspto-grants-2016_09 |
| ORD ID | ord-b6bbcaddc602441fb993e88401c55cd9 |
| 出典メモ | uspto-grants-2016_09 |