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1-Propanol → 3-Propoxy-4-nitrotoluene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Propanol | HCID 1031 | — |
| 反応物 | 2-Aminothiazole | HCID 2155 | — |
| 反応物 | Benzene, 2-fluoro-4-methyl-1-nitro- | HCID 67966 | — |
| 反応物 | 4-Methyl-2-propoxyaniline | HCID 24698653 | — |
| 生成物 | 1-(4-Methyl-2-propoxy-phenyl)-3-thiazol-2-yl-urea | HCID 47363896 | 75% |
| 生成物 | 3-Propoxy-4-nitrotoluene | HCID 58255524 | 80% |
反応手順
3-Propoxy-4-nitrotoluene (0.79 g, 80%) was prepared from 1-propanol and 3-fluoro-4-nitrotoluene (0.77 g, 5.0 mmol) following the general procedure G. This was reduced to 4-methyl-2-propoxyaniline (0.54 g, 82%) following general procedure C. 1-(4-Methyl-2-propoxy-phenyl)-3-thiazol-2-yl-urea (220 mg, 75%) was prepared from 4-methyl-2-propoxyaniline (165 mg, 1.0 mmol) and 2-aminothiazole (100 mg, 1.0 mmol) following the general procedure D.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07897628B2 |
| 出典データセット | uspto-grants-2011_03 |
| ORD ID | ord-ebb0f059b28c4134acbd0067699eb790 |
| 出典メモ | uspto-grants-2011_03 |