化工社化工社 化学情報印刷レポート · 研究参考用
2-Aminothiazole → 4-(2-Methylpropoxy)-3-nitrobenzaldehyde
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Aminothiazole | HCID 2155 | — |
| 反応物 | Isobutanol | HCID 6560 | — |
| 反応物 | 4-Fluoro-3-nitrobenzaldehyde | HCID 598129 | — |
| 反応物 | 5-Formyl-2-(2-methylpropoxy)aniline | HCID 82057088 | — |
| 生成物 | 4-(2-Methylpropoxy)-3-nitrobenzaldehyde | HCID 28829481 | 75% |
| 生成物 | 1-(5-Formyl-2-isobutoxy-phenyl)-3-thiazol-2-yl-urea | HCID 59732785 | 65% |
反応手順
4-(2-Methylpropoxy)-3-nitrobenzaldehyde (0.83 g, 75%) was prepared from 2-methyl-propanol (0.46 ml, 5.0 mmol) and 4-fluoro-3-nitrobenzaldehyde (0.77 g, 5.0 mmol) following the general procedure G. This was reduced to 5-formyl-2-(2-methylpropoxy)-aniline (0.49 g, 68%) following general procedure B. 1-(5-Formyl-2-isobutoxy-phenyl)-3-thiazol-2-yl-urea (208 mg, 65%) was prepared from 5-formyl-2-(2-methylpropoxy)aniline (193 mg, 1.0 mmol) and 2-aminothiazole (100 mg, 1.0 mmol) following the general procedure D.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07897628B2 |
| 出典データセット | uspto-grants-2011_03 |
| ORD ID | ord-e6a646d7ceaf4ef6bf64da9efa8dac4e |
| 出典メモ | uspto-grants-2011_03 |