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Benzenemethanamine, 4-chloro-3-(trifluoromethyl)- → 4-((4-Chloro-3-(trifluoromethyl)benzyl)amino)benzo[d][1,2,3]triazine-8-carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzenemethanamine, 4-chloro-3-(trifluoromethyl)- | HCID 485440 | — |
| 反応物 | 4-oxo-1H-1,2,3-benzotriazine-8-carboxamide | HCID 178513613 | — |
| 生成物 | 4-((4-Chloro-3-(trifluoromethyl)benzyl)amino)benzo[d][1,2,3]triazine-8-carboxamide | HCID 76073575 | — |
反応手順
Compound 4 was prepared following general synthetic scheme 7 wherein (4-chloro-3-(trifluoromethyl)phenyl)methanamine was reacted with 4-hydroxybenzo[d][1,2,3]-triazine-8-carboxamide to give the title compound. LC-MS [382 (M+1)], 1H NMR (400 MHz, DMSO-d): δ 9.38-9.32 (m, 2H), 8.54 (d, 1H), 8.48 (d, 1H), 8.05 (s, 1H), 8.02-7.98 (m, 1H), 7.95 (s, 1H), 7.73-7.68 (m, 2H), 4.96 (d, 2H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09440968B2 |
| 出典データセット | uspto-grants-2016_09 |
| ORD ID | ord-33f2834b9c86443388921c0d203f1ac2 |
| 出典メモ | uspto-grants-2016_09 |