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Mercuric cyanide → 3-nitrophenyl 2,3,4-tri-O-acetyl-1,5-dithio-beta-D-xylopyranoside
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Mercuric cyanide | HCID 11591 | — |
| 反応物 | 3-Nitrobenzene-1-thiol | HCID 243576 | — |
| 反応物 | 2,3,4-tri-O-acetyl-5-thio-alpha-xylopyranosyl bromide | HCID 10926314 | — |
| 生成物 | 3-nitrophenyl 2,3,4-tri-O-acetyl-1,5-dithio-beta-D-xylopyranoside | HCID 14795355 | 27% |
反応手順
If the procedure described in Preparation I is followed starting from 10 g (64.5.10-3 mol) of 3-nitrobenzenethiol, 16.29 g (64.5.10-3 mol) of mercuric cyanide (Hg(CN)2) and 25.2 g (70.9.10-3 mol) of 2,3,4-tri-O-acetyl-5-thio-α-D-xylopyranosyl bromide, 7.44 g (yield: 27%) of the expected product are obtained after purification by flash chromatography using a toluene/ethyl acetate mixture (9/1 v/v) as the eluent, followed by crystallization from ether.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05246961 |
| 出典データセット | uspto-grants-1993_09 |
| ORD ID | ord-86b0005ef8c14e33b6bf5c9a49e82eb2 |
| 出典メモ | uspto-grants-1993_09 |