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Potassium Carbonate → HCID 67059839、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 4-Cyanophenol | HCID 13019 | — |
| 反応物 | 8-Bromo-2,6-dimethyloct-2-ene | HCID 4328245 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | HCID 67059839 | HCID 67059839 | 91.4% |
反応手順
A mixture of 4-cyanophenol (6.0 g, 50.0 mmol), potassium carbonate (27.6 g, 200 mmol) and citronellylbromide (13.15 g, 60.0 mmol) in acetone (200 mL) was heated under reflux for 24 hours. The solvent was evaporated and the residue was taken up with CH2Cl2 (60 mL×2) and the solution filtered. The solvent was evaporated and the resulting oil was purified by flash column chromatography over silica gel (EtOAc/hexanes 1:1) as eluant to give 4-[(3S)-3,7-dimethyl-6-octenyloxy]cyanobenzene (11.76 g, 45.7 mmol, 91.4% yield) as a white oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07902363B2 |
| 出典データセット | uspto-grants-2011_03 |
| ORD ID | ord-67f4c1c99a004d5c846fb66a11ed4185 |
| 出典メモ | uspto-grants-2011_03 |