Acetic Anhydride → (4-Bromopyridin-2-yl)methyl acetate

HRID 605957

反応式

HRID 605957 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][N+:5]([O-])=[C:4]([CH3:9])[CH:3]=1.[C:10]([O:13]C(=O)C)(=[O:12])[CH3:11]>C(Cl)Cl>[Br:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([CH2:9][O:13][C:10](=[O:12])[CH3:11])[CH:3]=1

参加物

4

反応物 2

HCID 7918Acetic AnhydrideHCID 544461394-Bromo-2-methyl-1-oxo-1lambda~5~-pyridine

生成物 1

HCID 45789873(4-Bromopyridin-2-yl)methyl acetate

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of 4-bromo-2-methylpyridine-1-oxide (4.00 g, 21.40 mmol) in DCM (20 mL) is added acetic anhydride (6 mL). The mixture is stirred at room temperature for 1 hour and then heated at reflux overnight. The solvent is removed under vacuum and the crude product is filtered through a silica plug, eluting with DCM to afford the title compound as an orange oil (815 mg).

後処理

  1. temperatureheated
  2. temperatureat reflux overnight
  3. customThe solvent is removed under vacuum
  4. filtrationthe crude product is filtered through a silica plug
  5. washeluting with DCM

出典と根拠

ORDレコード
ord-38636f2731b94ebe82902bd00ee169fc
出典データセット
uspto-grants-2011_03
特許番号
US07915256B2

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