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Ethanol hydrochloride → 4-(3,4-Difluorobenzyl)-4-hydroxypiperidine hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethanol hydrochloride | HCID 21887872 | — |
| 反応物 | Tert-butyl 4-(3,4-difluorobenzyl)-4-hydroxypiperidine-1-carboxylate | HCID 86680862 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 4-(3,4-Difluorobenzyl)-4-hydroxypiperidine hydrochloride | HCID 86680863 | — |
反応手順
To a solution of tert-butyl 4-(3,4-difluorobenzyl)-4-hydroxypiperidine-1-carboxylate (4.7 g) in ethanol (30 mL) was added 2.0 M HCl/ethanol solution (36 mL), and the mixture was stirred overnight at room temperature. The solvent was evaporated under reduced pressure, and the obtained solid was recrystallized from ethyl acetate/diisopropyl ether to give the title compound (3.5 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09440990B2 |
| 出典データセット | uspto-grants-2016_09 |
| ORD ID | ord-dc0cf333b11e4a979ca546b66958a5af |
| 出典メモ | uspto-grants-2016_09 |