化工社化工社 化学情報印刷レポート · 研究参考用
Phosphorus tribromide → 1-Bromo-4-(1-bromoethyl)benzene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Phosphorus tribromide | HCID 24614 | — |
| 反応物 | 1-(4-Bromophenyl)ethanol | HCID 95352 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 1-Bromo-4-(1-bromoethyl)benzene | HCID 9838146 | 75% |
反応手順
A solution of 1-(4-bromo-phenyl)-ethanol (4.21 g, 20.9 mmol) in 15 mL of CH2Cl2 was reacted with 15 mL of 1.0M PBr3 in CH2Cl2 at room temperature for 4 h. Quenched by pouring into ice and adjusted to pH 9 with 5% aqueous NaHCO3. Extracted with CH2Cl2 and dried over Na2SO4, filtered and concentrated under vacuum giving the title compound (4.1 g, 75%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07915411B2 |
| 出典データセット | uspto-grants-2011_03 |
| ORD ID | ord-a05d650c55e340159ff537fcf554041f |
| 出典メモ | uspto-grants-2011_03 |