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Dimethylformamide → (S)-5-Oxotetrahydrofuran-2-carbonyl chloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | Oxalyl chloride | HCID 65578 | — |
| 反応物 | (2S)-5-oxooxolane-2-carboxylic acid | HCID 636468 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | (S)-5-Oxotetrahydrofuran-2-carbonyl chloride | HCID 10975648 | 87.4% |
反応手順
To a solution of (2S)-5-oxotetrahydrofuran-2-carboxylic acid (compound 28a, 70 g, 539 mmol) and a drop of DMF in anhydrous DCM (500 mL) was added oxalyl dichloride (137 g, 1.07 mol) dropwise. The reaction mixture was stirred at room temperature for 3 hours. The reaction was then concentrated in vacuo to afford 70 g crude product of (2S)-5-oxotetrahydrofuran-2-carbonyl chloride (compound 28b), which was used in next step without further purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09441008B2 |
| 出典データセット | uspto-grants-2016_09 |
| ORD ID | ord-77eed8f0a2d446d19676e36e967d82c0 |
| 出典メモ | uspto-grants-2016_09 |