化工社化工社 化学情報印刷レポート · 研究参考用
HRID 60799作成日：2026年10月23日
Diisopropylethylamine → rac-cis-(5-(4-Fluorophenyl)-2-methylthiazol-4-yl)(2-(((4-methoxypyrimidin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)methanone
https://huagongshe.com/ja/reaction/60799
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | 2-Chloro-4-methoxypyrimidine | HCID 588935 | — |
| 反応物 | Rac-cis-(2-(aminomethyl)-3-methylpiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone | HCID 117727897 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 生成物 | rac-cis-(5-(4-Fluorophenyl)-2-methylthiazol-4-yl)(2-(((4-methoxypyrimidin-2-yl)amino)methyl)-3-methylpiperidin-1-yl)methanone | HCID 131737127 | — |
反応手順
A mixture of rac-cis-(2-(aminomethyl)-3-methylpiperidin-1-yl)(5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone, 4-methoxy-2-chloropyrimidine, and DIPEA in isopropanol was stirred at 110° C. for 18 h. The reaction was cooled and concentrated in vacuo. The crude reaction mixture was purified by reverse-phase preparative HPLC to afford the title compound. MS (ESI) 456.02 (M+H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09440982B2 |
|---|
| 出典データセット | uspto-grants-2016_09 |
|---|
| ORD ID | ord-1d3c11367f7b4f488f0b06069359f832 |
|---|
| 出典メモ | uspto-grants-2016_09 |
|---|
