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Trifluoroacetic acid → N-((1-(Biphenylcarbonyl)-5-oxopiperidin-2-yl)methyl)quinoline-8-carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Trifluoroacetic acid | HCID 6422 | — |
| 反応物 | 8-Quinolinecarboxylic acid | HCID 66582 | — |
| 反応物 | N-((1-(biphenylcarbonyl)-5-methoxy-1,2,3,4-tetrahydropyridin-2-yl)methyl)quinoline-8-carboxamide | HCID 89740834 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | N-((1-(Biphenylcarbonyl)-5-oxopiperidin-2-yl)methyl)quinoline-8-carboxamide | HCID 89739334 | — |
反応手順
N-((1-(Biphenylcarbonyl)-5-oxopiperidin-2-yl)methyl)quinoline-8-carboxamide was prepared according general procedure A using quinoline-8-carboxylic acid and N-((1-(biphenylcarbonyl)-5-methoxy-1,2,3,4-tetrahydropyridin-2-yl)methyl)quinoline-8-carboxamide which was synthesized from the product from Part VI above, following ketal cleavage using TFA and CH2Cl2. MS (ESI) 464 (M+H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09440982B2 |
| 出典データセット | uspto-grants-2016_09 |
| ORD ID | ord-79d459c41a05423997f37c19c5489e52 |
| 出典メモ | uspto-grants-2016_09 |