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5-Amino-2-methylphenol → 7-Ethoxy-4-[(3-hydroxy-4-methylphenyl)amino]-6-methoxy-3-quinolinecarbonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5-Amino-2-methylphenol | HCID 17818 | — |
| 反応物 | 4-Chloro-7-ethoxy-6-methoxy-3-quinolinecarbonitrile | HCID 10563473 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 7-Ethoxy-4-[(3-hydroxy-4-methylphenyl)amino]-6-methoxy-3-quinolinecarbonitrile | HCID 22466752 | 54.8% |
反応手順
A mixture of 500 mg (1.90 mmol) 4chloro-7ethoxy-6-methoxy-3-quinolinecarbonitrile, 30 ml ethanol, and 281 mg (2.28 mmol) 3-hydroxy-4-methylaniline was heated to reflux under N2 overnight. Removed heat and made basic with saturated sodium bicarbonate. Stripped solvents and slurried residue in hexane. Collected solids, washed with water, and dried in vacuo, giving 364 mg off-white solid: mass spectrum (electrospray m/e): M+H=349.9.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06002008 |
| 出典データセット | uspto-grants-1999_12 |
| ORD ID | ord-2257594767904b8c8d0de3e04236adb3 |
| 出典メモ | uspto-grants-1999_12 |