関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | (R)-Methyl 2-amino-3-phenylpropanoate | HCID 853474 | — |
| 触媒 | L-Phenylalanine, methyl ester | HCID 736234 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | methyl (2R)-2-amino-3-phenylpropanoate;hydrochloride | HCID 11481330 | 78.8% |
反応手順
An aqueous solution of 153.2 mmol of D-phenylalanine methyl ester and 4.6 mmol of L-phenylalanine methyl ester (D/L ratio=97.1/2.9) and 335 mmol of HCl in 400 ml of pure water was neutralized to pH 3 with a 20% NaOH aqueous solution and concentrated to a weight of 100 g by means of a rotary evaporator. The concentrate was cooled to about 2° C., and the precipitated crystals were collected by filtration by suction. There was obtained 120.7 mmol of D-phenylalanine methyl ester hydrochloride having an optical purity of 99.97% as measured by HPLC.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US06008403 |
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| 出典データセット | uspto-grants-1999_12 |
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| ORD ID | ord-a88b643517434cb992fa6cae6c5fd4a5 |
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| 出典メモ | uspto-grants-1999_12 |
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