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Pyridine → 5-Methoxy-2-(3-nitrobenzoyl)aminobenzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pyridine | HCID 1049 | — |
| 反応物 | Benzoyl chloride, 3-nitro- | HCID 8495 | — |
| 反応物 | 2-Amino-5-methoxybenzamide | HCID 20338217 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | 5-Methoxy-2-(3-nitrobenzoyl)aminobenzamide | HCID 59361943 | 133.6% |
反応手順
To a suspension of 2-amino-5-methoxybenzamide (2.42 g, 14.6 mmol) and pyridine (6 mL) in CHCl3 (120 mL) was added 3-nitrobenzoyl chloride (3.0 g, 16.1 mmol). The resulting mixture was stirred at RT for 6 h. The volatiles were removed in vacuo and the resultant solid was washed with Et2O to give the 5-Methoxy-2-(3-nitrobenzoyl)aminobenzamide (6.15 g) which was taken directly on to the next step. HPLC retention time 6.58 mins.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09440961B2 |
| 出典データセット | uspto-grants-2016_09 |
| ORD ID | ord-fc159f7e15dc4e17a0f43b00764ca618 |
| 出典メモ | uspto-grants-2016_09 |