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Cyclohexyl isocyanate → 1-Cyclohexyl-3-[6-(2,6-dichlorophenyl)-2-{[4-(diethylamino)butyl]amino}pyrido[2,3-d]pyrimidin-7-yl]urea
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Cyclohexyl isocyanate | HCID 18502 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 6-(2,6-dichlorophenyl)-2-N-[4-(diethylamino)butyl]pyrido[2,3-d]pyrimidine-2,7-diamine | HCID 5328133 | — |
| 反応物 | Acetonitrile methanol | HCID 21959252 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 1-Cyclohexyl-3-[6-(2,6-dichlorophenyl)-2-{[4-(diethylamino)butyl]amino}pyrido[2,3-d]pyrimidin-7-yl]urea | HCID 5328136 | 71.9% |
反応手順
6-(2, 6-Dichlorophenyl)-N2 -(4-diethylamino-butyl)-pyrido[2,3-d]pyrimidine-2,7-diamine (1.0 g) from Example 53 in DMF (15 mL) was reacted with 60% sodium hydride suspension (0.092 g) and cyclohexyl isocyanate (0.289 g) according to the general procedure of Example 54 to give 0.927 g of the title compound, ESMS (20/80 MeOH/CH3CN+0.1% AcOH): M+ +H=558, 433.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05952342 |
| 出典データセット | uspto-grants-1999_09 |
| ORD ID | ord-31a0e7741e3a42f2a6c7b1404d737440 |
| 出典メモ | uspto-grants-1999_09 |