関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 2-(Ethylamino)ethanol | HCID 8072 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 4-Fluorobenzaldehyde | HCID 68023 | — |
| 溶媒 | Dimethyl Sulfoxide | HCID 679 | — |
| 生成物 | 4-(Ethyl(2-hydroxyethyl)amino)benzaldehyde | HCID 639857 | — |
反応手順
To a three neck flask fitted with a mechanical stirrer, a thermometer, and a condenser, is added 124 g (1 mole) of 4-fluorobenzaldehyde, 89.1 g (1 mole) of 2-(N-ethylamino)ethanol, 138.2 g (1 mole) of anhydrous potassium carbonate, and dimethylsulfoxide. The mixture is heated at 95° C. for 3 hours. After cooling to room temperature, the solution is poured into a four-fold excess of ice water, and the solid product is collected by filtration and recrystallized from water.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05247042 |
|---|
| 出典データセット | uspto-grants-1993_09 |
|---|
| ORD ID | ord-5e96e77a6ea242f0b4bfc5496ffdd983 |
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| 出典メモ | uspto-grants-1993_09 |
|---|
