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2-Propenoic acid, 2-cyano-3-ethoxy-, ethyl ester → 5-Amino-1-(3,5-dichloro-pyrid-2-yl)-4-ethoxycarbonyl-pyrazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Propenoic acid, 2-cyano-3-ethoxy-, ethyl ester | HCID 78943 | — |
| 反応物 | 3,5-Dichloro-2-hydrazinylpyridine | HCID 600966 | — |
| 溶媒 | 1-Ethoxyethanol | HCID 10129898 | — |
| 生成物 | 5-Amino-1-(3,5-dichloro-pyrid-2-yl)-4-ethoxycarbonyl-pyrazole | HCID 13755230 | 98.3% |
反応手順
16.9 g (0.1 mole) of ethyl ethoxymethylenecyanoacetate and 17.8 g (0.1 mole) of 3,5-dichloro-pyrid-2-ylhydrazine in 150 ml of ethoxyethanol are stirred at 80° C. for 5 hours and then at 120° C. for a further 2 hours. For working up, the solvent is removed in vacuo. 29.6 g (98% of theory) of 5-amino-1-(3,5-dichloro-pyrid-2-yl)-4-ethoxycarbonyl-pyrazole of melting point 98°-101° C. are obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04772312 |
| 出典データセット | uspto-grants-1988_09 |
| ORD ID | ord-c998c34efefb4ee99bb0ca2dbd3a393b |
| 出典メモ | uspto-grants-1988_09 |