関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Cyclohexanethiol | HCID 15290 | — |
| 反応物 | Methyl 6-bromopyridine-2-carboxylate | HCID 16217886 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 6-Cyclohexylsulfanyl-pyridine-2-carboxylic acid methyl ester | HCID 90118251 | 46.4% |
反応手順
After 6-bromo-pyridine-2-carboxylic acid methyl ester (0.30 g, 1.39 mmol) was dissolved in DMF (4 mL), K2CO3(0.575 g, 4.16 mmol) and cyclohexanethiol (0.25 mL, 2.08 mmol) were added thereto in turn, and the mixture was stirred at 70° C. for 18 hours. After the termination of the reaction, the reactant was concentrated under reduced pressure, extracted with EtOAc, and purified by column chromatography (eluent, EtOAc/Hex=1/5) to obtain the title compound (0.162 g, 46%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09447044B2 |
|---|
| 出典データセット | uspto-grants-2016_09 |
|---|
| ORD ID | ord-5de57498ae4f48acbce22a701ea55cc6 |
|---|
| 出典メモ | uspto-grants-2016_09 |
|---|
