化工社化工社 化学情報印刷レポート · 研究参考用
L-phenylalanine cyclopentyl ester tosylate → cyclopentyl N-[2-(1-{[2,4-dihydroxy-5-(propan-2-yl)phenyl]carbonyl}piperidin-4-yl)ethyl]-L-phenylalaninate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | L-phenylalanine cyclopentyl ester tosylate | HCID 86629432 | — |
| 反応物 | 2-(1-{[2,4-Bis(benzyloxy)-5-(prop-1-en-2-yl)phenyl]carbonyl}piperidin-4-yl)acetaldehyde | HCID 86686420 | — |
| 生成物 | cyclopentyl N-[2-(1-{[2,4-dihydroxy-5-(propan-2-yl)phenyl]carbonyl}piperidin-4-yl)ethyl]-L-phenylalaninate | HCID 54766972 | — |
反応手順
Prepared from Intermediate D and L-phenylalanine cyclopentyl ester tosylate. 1H NMR (300 MHz, d3-MeOD) 7.44-7.17 (5H, m), 6.95 (1H, s), 6.34 (1H, s), 5.17, (1H, m), 4.35-4.12 (4H, m), 3.46-3.35 (1H, m), 3.27-2.85 (6H, m), 1.93-1.21, (13H, m), 1.19 (6H, d, J=7.0 Hz). LC/MS: purity 98.4%, m/z 523 [M+H]+
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09321718B2 |
| 出典データセット | uspto-grants-2016_04 |
| ORD ID | ord-180aeae9063a4499a5dcb418e860a8db |
| 出典メモ | uspto-grants-2016_04 |