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N-(Phenylmethyl)thiourea → N-benzyl-4-(pyridin-2-yl)thiazol-2-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-(Phenylmethyl)thiourea | HCID 737375 | — |
| 反応物 | 2-Bromo-1-(2-pyridinyl)-1-ethanone hydrobromide | HCID 2776231 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | N-benzyl-4-(pyridin-2-yl)thiazol-2-amine | HCID 2902584 | — |
反応手順
A solution of 2-(Bromoacetyl)pyridine hydrobromide (100 mg, 0.36 mmol) in ethanol (2 mL) was treated with 1-benzyl-2-thiourea (90 mg, 0.54 mmol). The resulting yellow solution was concentrated, and the crude residue was purified on reverse phase HPLC to produce N-benzyl-4-(pyridin-2-yl)thiazol-2-amine.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09321761B2 |
| 出典データセット | uspto-grants-2016_04 |
| ORD ID | ord-12ad8a3d918842789af2cb1dad38d843 |
| 出典メモ | uspto-grants-2016_04 |