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5-Bromo-3-pyridinecarboxaldehyde → (E)-5-(2-cyclohexylvinyl)nicotinaldehyde
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5-Bromo-3-pyridinecarboxaldehyde | HCID 2784734 | — |
| 反応物 | (2-Cyclohexylvinyl)boronic acid | HCID 6031024 | — |
| 生成物 | (E)-5-(2-cyclohexylvinyl)nicotinaldehyde | HCID 86694593 | — |
反応手順
Coupling of (E)-(2-cyclohexylvinyl)boronic acid with 5-bromonicotinaldehyde following the method used in Example 3 gave (E)-5-(2-cyclohexylvinyl)nicotinaldehyde as a yellow oil. Yield (0.8 g, 69%); 1H NMR (400 MHz, DMSO-d6) δ 10.08 (s, 1H), 8.32 (s, 1H), 8.75 (s, 1H), 8.28 (s, 1H), 6.51-6.38 (m, 2H), 2.26-2.13 (m, 1H), 1.88-1.58 (m, 5H), 1.42-1.18 (m, 5H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09447078B2 |
| 出典データセット | uspto-grants-2016_09 |
| ORD ID | ord-1cea7e4aa0cd4637bb420b42784e85a3 |
| 出典メモ | uspto-grants-2016_09 |