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1,4-Dimercapto-2,3-butanediol → 1-[2-(4-Methylpiperazin-1-yl)ethyl]-3-(6-sulphanyl-1,3-benzothiazol-2-yl)urea
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1,4-Dimercapto-2,3-butanediol | HCID 19001 | — |
| 反応物 | 1-(6-Thiocyanato-1,3-benzothiazol-2-yl)-3-[2-(4-methylpiperazin-1-yl)ethyl]urea | HCID 86647881 | — |
| 触媒 | Monobasic potassium phosphate | HCID 516951 | — |
| 生成物 | 1-[2-(4-Methylpiperazin-1-yl)ethyl]-3-(6-sulphanyl-1,3-benzothiazol-2-yl)urea | HCID 86647880 | 40.7% |
反応手順
The 1-[2-(4-methylpiperazin-1-yl)ethyl]-3-(6-sulphanyl-1,3-benzothiazol-2-yl)urea was prepared according to the method described in Example 1b, but using 1 g of 1-(6-thiocyanato-1,3-benzothiazol-2-yl)-3-[2-(4-methylpiperazin-1-yl)ethyl]urea, 14 mg of potassium dihydrogen phosphate and 1.16 g of DL-dithiothreitol. 380 mg of 1-[2-(4-methylpiperazin-1-yl)ethyl]-3-(6-sulphanyl-1,3-benzothiazol-2-yl)urea are thus obtained in the form of a white solid, the characteristics of which are as follows:
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09321777B2 |
| 出典データセット | uspto-grants-2016_04 |
| ORD ID | ord-9798316fa0f24c03bb298040c767c9d3 |
| 出典メモ | uspto-grants-2016_04 |