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Acetic Acid → alpha-(2-fluorophenyl)-N-t-butylnitrone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | 2-Methyl-2-nitropropane | HCID 11672 | — |
| 反応物 | o-Fluorobenzaldehyde | HCID 67970 | — |
| 触媒 | Zinc | HCID 23994 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | alpha-(2-fluorophenyl)-N-t-butylnitrone | HCID 85599391 | — |
反応手順
To a suspension of 2-fluorobenzaldehyde (332.3 mg, 2.68 mmol), 1,1-dimethylnitroethane (547.5 mg, 5.31 mmol) and zinc (514.6 mg, 7.87 mmol) in ethanol (3.0 ml) was added acetic acid (940.2 mg, 15.7 mmol) dropwise at 5° C. while stirring. The mixture was stirred at room temperature for 6.5 hours. Zinc acetate in the mixture was filtered off and the filtrate was concentrated and purified by silica gel chromatography (hexane/ethyl acetate=4/1 to 2/1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06194461B1 |
| 出典データセット | uspto-grants-2001_02 |
| ORD ID | ord-61d658cb9eb749bda8fe13737e290f2a |
| 出典メモ | uspto-grants-2001_02 |