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Ethyl formate → Ethyl 2-formyl-3-(6-methyl-3-pyridyl)propionate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl formate | HCID 8025 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | Ethyl 3-(6-methyl-3-pyridyl)propionate | HCID 3018102 | — |
| 溶媒 | 1,2-Dimethoxyethane | HCID 8071 | — |
| 生成物 | Ethyl 2-formyl-3-(6-methyl-3-pyridyl)propionate | HCID 3018359 | — |
反応手順
Ethyl 3-(6-methyl-3-pyridyl)propionate was reacted at 0° with ethyl formate and sodium hydride in 1,2-dimethoxyethane to give ethyl 2-formyl-3-(6-methyl-3-pyridyl)propionate, m.p. 142°-144°, which was heated under reflux with dried nitroguanidine and sodium methoxide in methanol to give 2-nitroamino-5-(6-methyl-3-pyridylmethyl)-4-pyrimidone, m.p. 215°-6° (decomp).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04558128 |
| 出典データセット | uspto-grants-1985_12 |
| ORD ID | ord-013352e85b104d35b429f734d72172f5 |
| 出典メモ | uspto-grants-1985_12 |