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2-Amino-3-phenylbutanoic acid → 5-chloro-N-[(1S)-1-cyclohexyl-2-hydroxyethyl]thiophene-2-sulfonamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Amino-3-phenylbutanoic acid | HCID 64808 | — |
| 反応物 | Alloisoleucine, DL- | HCID 99288 | — |
| 反応物 | (alphaS)-alpha-Aminocyclohexaneacetic acid | HCID 736848 | — |
| 反応物 | 5-Bromothiophene-2-sulfonyl chloride | HCID 2733924 | — |
| 反応物 | 5-Chlorothiophene-2-sulfonyl chloride | HCID 2733925 | — |
| 生成物 | 5-chloro-N-[(1S)-1-cyclohexyl-2-hydroxyethyl]thiophene-2-sulfonamide | HCID 12987475 | — |
反応手順
The following compounds (Examples 12-17, Table 4) were prepared using 5-chlorothiophene-2-sulfonyl chloride, and 5-bromothiophene-2-sulfonyl chloride with L-cyclohexylglycine, β-methyl-DL-phenylalanine, and L-allo-isoleucine and following the procedure outlined in Example 12.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07691884B2 |
| 出典データセット | uspto-grants-2010_04 |
| ORD ID | ord-6335f1b20dfd47f3bf580483ae39ca30 |
| 出典メモ | uspto-grants-2010_04 |