化工社化工社 化学情報印刷レポート · 研究参考用
Triethylamine → 1-Methylpiperidin-4-yl methanesulfonate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Methanesulfonyl chloride | HCID 31297 | — |
| 反応物 | 4-Piperidinol, 1-methyl- | HCID 66048 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 1-Methylpiperidin-4-yl methanesulfonate | HCID 4190681 | 99.9% |
反応手順
1-Methylpiperidin-4-ol (4 g, 34.7 mmol) was dissolved in CH2Cl2 (70 ml) at 0° C. followed by the addition of Et3N (10 ml, 69.4 mmol, 2 eq.) and methanesulfonyl chloride (2.7 ml, 34.7 mmol, 1 eq.). The mixture was stirred at RT for 3 h and quenched and extracted as in Intermediate Example 5(a). The solvent was distilled off to afford the crude product (6.7 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09447091B2 |
| 出典データセット | uspto-grants-2016_09 |
| ORD ID | ord-95d2427a2ebc434081e05472c18fdde3 |
| 出典メモ | uspto-grants-2016_09 |