化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → 1,2,3,9-Tetrahydro-9-methyl-3-methylene-4H-carbazol-4-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Formaldehyde | HCID 712 | — |
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | 9-Methyl-1,2,3,9-tetrahydro-4H-carbazol-4-one | HCID 598875 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | 1,2,3,9-Tetrahydro-9-methyl-3-methylene-4H-carbazol-4-one | HCID 11790505 | — |
反応手順
Accordingly, 1,2,3,9-tetrahydro-9-methyl-3-methylene-4H-carbazol-4-one was synthesized from 1,2,3,9-tetrahydro-9-methyl-4H-carbazol-4-one using a formaldehyde reagent (paraformaldehyde) and a mineral acid (HCl) in an aprotic solvent (DMF). Note that this reaction was rapid and high yielding, even though it was performed without using glacial acetic acid as a solvent, and without using a secondary amine as a catalyst.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07696356B2 |
| 出典データセット | uspto-grants-2010_04 |
| ORD ID | ord-1aef5c842c6b48729cb0ba28b1f33527 |
| 出典メモ | uspto-grants-2010_04 |