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N2 acetyl-9-(1,3-dibenzyloxy-2-propoxymethyl)guanine → N2 acetyl-9-(1,3-dihydroxy-2-propoxymethyl)guanine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N2 acetyl-9-(1,3-dibenzyloxy-2-propoxymethyl)guanine | HCID 136408872 | — |
| 反応物 | HCID 178418361 | HCID 178418361 | — |
| 触媒 | Palladium hydroxide | HCID 9942167 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | N2 acetyl-9-(1,3-dihydroxy-2-propoxymethyl)guanine | HCID 136408871 | 44.5% |
反応手順
To a solution of N2 -acetyl-9-(1,3-dibenzyloxy-2-propoxymethyl)guanine (4.62 g, 9.67 mmol) in 150 ml of methanol plus 40 ml of water was added 20% palladium hydroxide on carbon as a slurry in 10 ml of water. The mixture was hydrogenated on a Parr hydrogenator at 60 psi of hydrogen for 38 hours then filtered through celite and concentrated to a white solid. Recrystallization from methanol/ethyl acetate gave 1.4 g of N2 -acetyl-9-(1,3-dihydroxy-2-propoxymethyl)guanine, mp 205°-208° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04609661 |
| 出典データセット | uspto-grants-1986_09 |
| ORD ID | ord-c7510ebc476b4471939c56a9e4acb995 |
| 出典メモ | uspto-grants-1986_09 |