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Toluene → HCID 22847666、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Toluene | HCID 1140 | — |
| 反応物 | 1H-Imidazole-5-carboxaldehyde, 2-butyl-1-[(2-chlorophenyl)methyl]- | HCID 10107530 | — |
| 反応物 | (S)-Methyl 2-amino-3-(thiophen-2-yl)propanoate | HCID 10899351 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | HCID 22847666 | HCID 22847666 | — |
反応手順
A solution of 2-n-butyl-1-[(2-chlorophenyl)methyl]-1H-imidazol-5-carboxaldehyde (0.6 g, 2.12 mmol), β-(2-thienyl)alanine methyl ester (0.4 g, 2.16 mmol) and toluene (25 ml) was refluxed under argon with a Dean-Stark water separator for 8 hours. The solvent was evaporated to an orange-red oil (1.1 g) of the title imine whose NMR was consistent with the structure.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05248689 |
| 出典データセット | uspto-grants-1993_09 |
| ORD ID | ord-7b25920dfe6144a1a723eec9437b7937 |
| 出典メモ | uspto-grants-1993_09 |