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HCID 19936753、化合物 → 2-n-butyl-1-(2-chloro-6-fluorophenyl)methyl-1H-imidazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | HCID 19936753 | HCID 19936753 | — |
| 反応物 | N-[2-{1 [(2-chlorophenyl)methyl]-2-n-butyl-1H-imidazol-5-yl}ethyl]phenylalanine | HCID 54198642 | — |
| 生成物 | 2-n-butyl-1-(2-chloro-6-fluorophenyl)methyl-1H-imidazole | HCID 19936774 | — |
反応手順
The procedures of Example 1(ii iii) were used. From 7.63 g of crude 2-n-butyl-1-(2-chloro-6-fluorophenyl)methyl-1H-imidazole was obtained 2.8 q of 2-n-butyl-1-(2-chloro-6-fluorophenyl)methyl-5-hydroxymethyl-1H-imidazo le; mp 106°-108° C. (from ethyl acetate). This material was oxidized with manganese dioxide and worked up as described to give 0.88 g (63%) of 2-n butyl-2-(2-chloro-6-fluorophenyl)methyl-1H-imidazol-5-carboxaldehyde; mp 88°-90° C. (from ethyl acetate).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05248689 |
| 出典データセット | uspto-grants-1993_09 |
| ORD ID | ord-d2c9533997c74d79a948283e529ded3f |
| 出典メモ | uspto-grants-1993_09 |