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Methanol → 8-(4'-Carboxymethyloxyphenyl)-1,3-dipropylxanthine 2-(biotinylamino)ethylamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | Diethyl Ether | HCID 3283 | — |
| 反応物 | 8-(4-Carboxymethyloxy)phenyl-1,3-dipropylxanthine | HCID 126079 | — |
| 反応物 | N-Hydroxysuccinimido-d-biotin | HCID 129676281 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 8-(4'-Carboxymethyloxyphenyl)-1,3-dipropylxanthine 2-(biotinylamino)ethylamide | HCID 131714856 | — |
反応手順
Compound 6d (24.1 mg, 0.056 mmol) was suspended in 1 ml DMF. N-Hydroxysuccinimido-d-biotin (Sigma, 23.6 mg, 0.069 mmol) was added with stirring. A solution formed after several minutes, and a precipitate appeared soon thereafter. After one day methanol (1 ml) and ether were added. The precipitate was collected and dried (yield 26.6 mg, 73%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04612315 |
| 出典データセット | uspto-grants-1986_09 |
| ORD ID | ord-eb793162060e4d608a6c1a06068b387a |
| 出典メモ | uspto-grants-1986_09 |