化工社化工社 化学情報印刷レポート · 研究参考用
2-Chlorobenzylamine → 1-Chloro-2-(isocyanatomethyl)benzene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Chlorobenzylamine | HCID 66648 | — |
| 反応物 | Triphosgene | HCID 94429 | — |
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 1-Chloro-2-(isocyanatomethyl)benzene | HCID 2733367 | 232.7% |
反応手順
To a solution of 2-chlorobenzylamine (1.0 g, 7.06 mmol) in a mixture of CH2Cl2 and H2O (10 mL/10 mL), triphosgene (838 mg, 2.82 mmol) and NaHCO3 (1.78 g, 21.2 mmol) were added. The reaction mixture was stirred at room temperature for 16 hours. Then the reaction mixture was partitioned between CH2Cl2 and water. The combined organic layers are dried over MgSO4 and filtered. The solvent was evaporated to give the desired product (1.1 g, 93%). EI-MS m/z 168.7 (M+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06271261B1 |
| 出典データセット | uspto-grants-2001_08 |
| ORD ID | ord-291c8d96be1d44cfb70e9e6690479ef3 |
| 出典メモ | uspto-grants-2001_08 |